Narrative Review of Hypercoagulability in Small-Vessel Vasculitis

Small-vessel and medium-vessel vasculitis.

Introduction The vasculitides include a broad spectrum of disorders that span a clinical spectrum from benign, self-limited disease to fulminant conditions that are fatal in the absence of therapy. Whereas the large-vessel vasculitides consist of 2 principal disorders, giant cell arteritis and Takayasu arteritis, the mediumand small-vessel vasculitides are much more diverse, including multiple ...

ANCA-associated small-vessel vasculitis.

Antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis is the most common primary systemic small-vessel vasculitis to occur in adults. Although the etiology is not always known, the incidence of vasculitis is increasing, and the diagnosis and management of patients may be challenging because of its relative infrequency, changing nomenclature, and variability of clinical expression. ...

Outcome in small-vessel systemic vasculitis.

Treatment of ANCA-Negative Small Vessel Vasculitis

Cryoglobulinaemia refers to circulating cryoglobulins. Cryoglobulins are immunoglobulins, which precipitate in temperatures below 37oC and dissolve upon rewarming [2]. Cryoglobu‐ linaemia is classified in 3 types based on clonality and immunoglobulin class. In particular, type I consists of monoclonal IgM or IgG immunoglobulin, type II is a mixture of monoclo‐ nal IgM and polyclonal IgG, while ...

Familial clusters of ANCA small-vessel vasculitis

Small-vessel vasculitides associated with the presence of antineutrophil cytoplasmic antibodies in the serum are characterized by inflammation and necrosis of small vessels. A pauci-immune necrotizing crescentic glomerulonephritis typically occurs when there is renal damage. Pathogenesis of these diseases remains unclear although infectious, genetic and environmental factors have been involved....